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Comfort Inn & Suites Sikeston I-55 Exterior photo

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Key details

About the Hotel

109 Matthews Lane, Sikeston, 63801

Close to the Sikeston Depot Museum & Gallery

Very good

7.9

8.1

/10

3.6

Loved by Comfort Inn & Suites Sikeston I-55 guests

extra large room

free upgrade

Big hot breakfast

clean pool

comfortable beds

"The handicap rooms in this hotel are pretty good."

Allen A from United States

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"Big hot breakfast , pool, hot tub and sauna."

mike b from United States

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"The room was very clean and the staff very helpful and friendly!"

Lee from United States

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"The rooms offer plenty of space."

Laura from Canada

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"Close to everything in town"

Avery from United States

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Comfort Inn & Suites Sikeston I-55: Convenient Gateway with On-Site Dining

Location

Comfort Inn & Suites Sikeston I-55 is positioned directly off Interstate 55, providing easy access to regional attractions including the Sikeston Depot Museum and Old Town Park. Nearby, guests can explore the scenic landscapes of the Missouri Bootheel. The hotel is also located close to local dining and shopping options just a short drive away.

Rooms

The hotel offers a variety of room types, including double queen and king beds aimed at accommodating both solo travelers and families. Select rooms come equipped with refrigerators and microwaves for added convenience during stays. Accessible rooms are available to ensure comfort for guests with mobility needs.

Dining

Guests enjoy complimentary hot breakfast daily, featuring a selection of hearty options to kick-start the day. The on-site restaurant, serving lunch and dinner, offers a diverse menu for those who prefer to dine-in. Coffee and tea service is available throughout the day to enhance the dining experience.

Business Facilities

The hotel provides a business center with printing and fax services for corporate travelers. Meeting spaces are also available for small gatherings or conferences, accommodating diverse business needs. High-speed internet access in public areas supports seamless connectivity.

Family-Friendly Accommodations

Children can enjoy the on-site play area, providing opportunities for outdoor fun. The hotel's central location allows easy access to family-friendly attractions in Sikeston. Spacious rooms accommodate families comfortably, ensuring everyone has enough space to relax.

Highlights

Location: Easy access to regional attractions

Rooms: Double queen and king beds

Dining: Complimentary hot breakfast

Business: Business center with printing services

Family-Friendly: On-site play area and spacious rooms

“The staff here certainly make check-in a smooth affair, a welcome start especially given its handy position for local dining. Rooms are kept tidy, with beds that provide a good night's rest, and the breakfast offerings, though standard, were surprisingly satisfying. It strikes a good balance for a convenient stopover.”

James DavidEditor-in-Chief at Usmissouri

Select your room type

Comfort Inn & Suites Sikeston I-55 offers a variety of rooms including double rooms, family rooms, and suites with breakfast, free cancelations, and special deals

King Room Non-Smoking
2 persons
33 sq. feet
1 King-size bed
room details
King Suite Non-Smoking
2 persons
33 sq. feet
1 King-size bed
room details
Queen Room Two Queen Beds Non-Smoking
2 persons
33 sq. feet
2 King Size Beds
room details

Show all rooms

Price and Room Availability Calendar

Check availability and prices for your dates now!

July 2026 - July 2027

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Check-in/ Check-out

Facilities

Comfort Inn & Suites Sikeston I-55 offers amenities for your comfortable stay and unforgettable experiences

Facilities: Very good

7.9/10Review score

General

Wi-Fi
Parking
Safe deposit box
Pets allowed

Children

Cots

Spa & Leisure

Indoor swimming pool

Bathroom

Washing machine

Media

AM/FM alarm clock

Location

109 Matthews Lane, Sikeston, 63801

Explore Sikeston

Local Highlights

Sikeston Depot Museum & Gallery

15-minute drive

Museum showcasing local history, artifacts, and art exhibits, perfect for families and history buffs. Features seasonal exhibits.

Sikeston Jaycee Bootheel Rodeo

10-minute drive

Annual rodeo featuring bull riding and live entertainment. A must-visit for fans of country culture, held every August.

Malco Sikeston Cinema and Grill

10-minute drive

Modern cinema offering a unique dining experience while enjoying the latest films. Perfect for couples on a casual night out.

Central Park

10-minute drive

Spacious park ideal for picnics and family activities, featuring walking trails and playgrounds. A great spot for relaxation.

Golfing at Boot Heel Golf Club

10-minute drive

Challenging 18-hole course suitable for all skill levels. Golf enthusiasts can book tee times in advance to secure a spot.

Yoga and Wellness Retreats

10-minute drive

Relaxing yoga sessions offered at local studios focusing on well-being. Ideal for solo travelers seeking rejuvenation.

El Nopalito Grill

4-minute walk

Charming Mexican restaurant known for its vibrant atmosphere and delicious tacos. Enjoy vegetarian options and margaritas.

Cheers Bar & Grille

10-minute drive

Casual spot with a friendly vibe and diverse menu, including burgers and salads. Ideal for families and those looking to unwind.

Malco Sikeston Cinema

10-minute drive

Catch the latest movies at this local cinema, featuring comfortable seating and a great menu. A favorite among movie lovers.

Local Live Music Venues

10-minute drive

Various venues host live music, from rock to country. Great for an evening out with friends or family-friendly shows.

Getting around

City Centre
Sikeston 8 min · 3.0 mi
Airports
Cape Girardeau Regional (CGI) 65 min · 26.7 mi
Barkley Regional (PAH) 135 min · 55.9 mi

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Property information and rules

Check-in

from 14:00-23:59

Check-out

until 11 am

Guest Parking

Private parking is possible on site for free.

Internet

Wireless internet is available in the entire hotel for free.

Breakfast

A buffet breakfast is served at affordable prices.

Children & extra beds

There are no cots provided in a room.

Pets

Pets are allowed on request.

Year renovated:

2007

Number of rooms:

Reviews and Ratings

Feedback about Comfort Inn & Suites Sikeston I-55 from previous guests about their experience.

Review score

Based on 157 verified reviews

8.0 /10

Great

79 %

Recommend

Cleanliness

8.1/10

Comfort

8.2/10

Facilities

7.9/10

Free WiFi

6.3/10

Location

8.8/10

Staff

8.6/10

Value for money

7.8/10

Pros

Spacious rooms

Helpful staff

Good breakfast

Accessible rooms

Cons

Difficult room door

Poor WiFi

Unsatisfactory cleaning

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COMFORT INN & SUITES SIKESTON I-55

About the Hotel

Loved by Comfort Inn & Suites Sikeston I-55 guests

Location

Rooms

Dining

Business Facilities

Family-Friendly Accommodations

Highlights

Select your room type

Price and Room Availability Calendar

Facilities

General

Children

Spa & Leisure

Bathroom

Media

Location

Reviews and Ratings

Next best alternative

Popular hotels all over the world